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Sheryl Lee Ralph has stepped into a lead role in the Broadway-aimed tuner adaptation of “The First Wives’ Club,” which recently began rehearsals for its out-of-town tryout at San Diego’s Old Globe Theater.

Ralph (“Dreamgirls,” “Thoroughly Modern Millie”) replaces Adriane Lenox, who bowed out due to health concerns, according to the Old Globe.

Actress joins Barbara Walsh and Karen Ziemba as a trio of women who are all dumped by their husbands for younger women.

Francesca Zambello (“The Little Mermaid”) directs the musical, with score by Motown songwriters Brian Holland, Lamont Dozier and Eddie Holland and book by Rupert Holmes (“Curtains”).

“First Wives” plays at the Old Globe July 17-Aug. 23. Specifics for the Broadway run, produced by Paul Lambert and Jonas Neilson, remain to be confirmed.