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Billy Bob Thornton and Tom Wilkinson are set to star with Julia Roberts and Clive Owen in "Duplicity," the Universal Pictures drama written and to be directed by Tony Gilroy.

Laura Bickford is producing with Jennifer Fox and Kerry Orent.

Wilkinson reteams with Gilroy right after he received a supporting actor Oscar nomination for the Gilroy-directed "Michael Clayton."

Thornton and Wilkinson will play the CEOs of rival pharmaceutical companies racing to corner the market on an innovation that will bring wild profits. Roberts and Owen play corporate spies who try to manipulate which corporation will win.Thornton recently wrapped "The Informers" and is filming the D.J. Caruso-directed drama "Eagle Eye" for DreamWorks; he will move directly into "Duplicity" in March. Wilkinson moved from "Valkyrie" to the Jay Roach-directed HBO film "Recount."